Guan Shu Hui’s (Paige Chua) domineering ways causes a rift between her husband Qi Hong Zhe (Thomas Ong) and his family. Hong Zhe is unhappy with his wife but chooses to put up with her, until Zhou Ke En (Tong Bing Yu) enters his life. Ke En is pretty, intelligent and most of all, she listens to Hong Zhe’s problem and supports his dreams. Ke En also manages to win the approval of Hong Zhe’s family, leaving Shu Hui feeling helpless. Shu Hui’s estranged mother Lu Xiu Zhu (Chen Li Ping) steps in and tries to salvage her daughter’s marriage. Xiu Zhu tries to outwit Ke En who is actually a malicious and mentally unstable woman. How will the battle between the mightiest mistress and the mightiest Mother-in-Law end? Will Shu Hui be able to save her marriage? 管淑慧（蔡琦慧）是个家庭主妇，她专制霸道的行为让身边的人都吃不消。丈夫齐宏哲（王沺裁）与家人都受不了她的自私和霸道，却敢怒不敢言。宏哲与灯饰设计师周可恩（童冰玉）邂逅，发现自己喜欢上她。可恩不但人长得漂亮，而且还聪明伶俐。不仅如此，和淑慧不同的是，她肯聆听他的心事，支持他的梦想。可恩还虏获了齐家上下的心，淑慧面临了婚姻问题还被众人排挤。淑慧的母亲吕秀珠决定帮女儿解决婚姻问题，化解母女之间的矛盾。秀珠就这样成为了淑慧的“军师”，与狡猾的可恩直接对抗。后来，秀珠发现她原来是职业小三，是个患有精神病的女人。这个最强岳母与最强小三的对决该怎么样收拾呢？淑慧该怎么样挽救她的婚姻呢？
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